1. Definitions: Systemic Inflammatory Response Syndrome (SIRS) SIRS describes a non-specific systemic inflammatory state, triggered by infectious or non-infectious insults. SIRS Criteria (Traditional) Presence of ≥2 of: Temperature >38°C or <36°C Heart rate >90/min Respiratory rate >20/min or PaCO₂ <32 mmHg WBC >12,000 or <4,000 or >10% bands SIRS can occur in: Trauma Burns Pancreatitis Post-operative states Infections SIRS is not equivalent to infection. Sepsis (Sepsis-3 Definition) According to the Surviving Sepsis Campaign and consensus definitions: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Operationalized as: Suspected/confirmed infection Increase in SOFA score ≥2 Septic Shock A subset of sepsis characterized by: Persistent hypotension requiring vasopressors Serum lactate >2 mmol/L despite adequate fluid resuscitation This carries a mortality >40%. Sho...
After Nearly seven months waiting, we finally have the good news:
Two big companies leading the race for COVID-19 vaccine have released promising results from their Phase 3 trials.
Pfizer and the German biotechnology company BioNTech announced early findings of their vaccine, BNT162b2 and
Moderna, a Cambridge, Massachusetts-based biotechnology company, mRNA-1273. final results for both are expected as soon as in few weeks.
Pfizer released the preliminary result that it's candidate vaccine was more than 95% effective while Moderna’s vaccine appears to be 94.5% effective. Both of the results stand the text of time.
Both candidate vaccines reported mild or moderate side effects, mostly pain at the injection site, fatigue and aching of muscles and joints for a day or two.
The Moderna and Pfizer vaccines are based on delivering strands of genetic material to turn people’s cells into factories of spike protein, which was found on the surface of the virus. Then the body sees the protein and designs immune soldiers to fight it upon future exposure.
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