Medspacedaily

​ 1. Definitions: Systemic Inflammatory Response Syndrome (SIRS) SIRS describes a non-specific systemic inflammatory state, triggered by infectious or non-infectious insults. SIRS Criteria (Traditional) Presence of ≥2 of: Temperature >38°C or <36°C Heart rate >90/min Respiratory rate >20/min or PaCO₂ <32 mmHg WBC >12,000 or <4,000 or >10% bands SIRS can occur in: Trauma Burns Pancreatitis Post-operative states Infections SIRS is not equivalent to infection. Sepsis (Sepsis-3 Definition) According to the Surviving Sepsis Campaign and consensus definitions: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Operationalized as: Suspected/confirmed infection Increase in SOFA score ≥2 Septic Shock A subset of sepsis characterized by: Persistent hypotension requiring vasopressors Serum lactate >2 mmol/L despite adequate fluid resuscitation This carries a mortality >40%. Sho...